Search and Contain: Impact of an Integrated Genomic and Epidemiological Surveillance and Response Program for Control of Carbapenemase-producing Enterobacterales

CR Lane; J Brett; M Schultz; CL Gorrie; K Stevens; DRM Cameron; S St George; A Van Diemen; M Easton; RL Stuart; M Sait; AY Peleg; AJ Stewardson; AC Cheng; DW Spelman; MJ Waters; SA Ballard; NL Sherry; DA Williamson; F Romanes; B Sutton; JC Kwong; T Seemann; A Goncalves Da Silva; N Stephens; BP Howden

Journal article

Search and Contain: Impact of an Integrated Genomic and Epidemiological Surveillance and Response Program for Control of Carbapenemase-producing Enterobacterales

CR Lane, J Brett, M Schultz, CL Gorrie, K Stevens, DRM Cameron, S St George, A Van Diemen, M Easton, RL Stuart, M Sait, AY Peleg, AJ Stewardson, AC Cheng, DW Spelman, MJ Waters, SA Ballard, NL Sherry, DA Williamson, F Romanes Show all

Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2021

DOI: 10.1093/cid/ciaa972

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Abstract

Background: Multiresistant organisms (MROs) pose a critical threat to public health. Population-based programs for control of MROs such as carbapenemase-producing Enterobacterales (CPE) have emerged and evaluation is needed. We assessed the feasibility and impact of a statewide CPE surveillance and response program deployed across Victoria, Australia (population 6.5 million). Methods: A prospective multimodal intervention including active screening, carrier isolation, centralized case investigation, and comparative pathogen genomics was implemented. We analyzed trends in CPE incidence and clinical presentation, risk factors, and local transmission over the program's first 3 years (2016-2018)..

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University of Melbourne Researchers

Courtney R Lane Author

Claire Gorrie Author

Michelle Sait Author

Norelle Sherry Author

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Funding Acknowledgements

This work was supported by the National Health and Medical Research Council through a partnership grant (grant number GNT1149991) and individual supporting grants (grant numbers GNT1142613 [to J. C. K.], GNT1123854 [to D. A. W.], GNT1105905 [to B. P. H.], GNT1141398 to [A. J. S]); N. L. S. and C. R. L. are supported by Australian Government Research Training Program scholarships and the Microbiological Diagnostic Unit Public Health Laboratory is funded by the Victorian Government.